The Blood-Brain Barrier Permeability of Ibogaine.

The blood-brain barrier (BBB) is a protective shield that selectively allows certain substances from the blood to enter the brain. Ibogaine, an alkaloid derived from the African shrub Tabernanthe iboga, is known for its potential in treating drug addiction and its psychoactive properties. Recent research suggests that Ibogaine can permeate the BBB, which is crucial for its neuropharmacological effects. This permeability is believed to facilitate its interaction with central nervous system targets, aiding in its potential therapeutic effects. However, while its ability to cross the BBB makes Ibogaine intriguing for medical use, it also underscores the importance of careful dosage and administration due to potential neurotoxic effects